Possibly Spoilers
I think there are different very very very sad moment...
- The worst is probably Aeris death. It destroyed me for days... :(
- Death of Biggs, Wedge and Jessie in ffvii.
- End of all FF (expecially X. I think they are all sad also cause I love them too much :P )
- Death of Sniper Wolf in mgs.
- Lisa mutation and death in sh.
- Death of Lavitz and end of Legend of Dragoon.
- The goodbye between Riku and Sora in kh.
- End of Resident Evil 0.